Current role
Head of Molecular and Cellular Biology at the Mary Lyon Centre at...
Head of Molecular and Cellular Biology at the Mary Lyon Centre at MRC Harwell
Role description
Lydia has over 25 years of experience of mouse genome engineering, with expertise in both classical and genome editing methods.
Professional credentials
PhD in Molecular and Cellular Biology, University of Nice
Current role
Head of Molecular and Cellular Biology at the Mary Lyon Centre at...
Research focus
Molecular biology; genome engineering and editing
Technical expertise
Genome engineering and editing; molecular assays for genomic and functional validation
Courses taught
Genome Engineering and Validation by Long Read Sequencing; Introduction to Editing the...
Lydia has over 25 years of experience of mouse genome engineering, with expertise in both classical and genome editing methods. She introduced the use of the CRISPR/Cas9 system at the MLC in 2013 and has employed these tools in both a high throughput process for the generation of null mice and a bespoke activity for the generation of point mutations and more complex mouse models. Her team has also defined quality control criteria and reliable protocols to validate mutants generated using CRISPR/Cas9 and classical tools. Lydia manages genome engineering activities and the development of new in vitro service platforms at the MLC. She has also helped to write the international guidelines for the reporting of the genetics of laboratory animals.
Through her involvement with the Advance Training Centre, Lydia brings extensive experience in molecular biology, helping to support the community in designing, creating and using genetically altered animals.
Accreditation and background
PhD in Molecular and Cellular Biology, University of Nice
Courses
Each course is designed to show its value clearly, including what you will learn, who it is for, who teaches it, and how it applies in real work.
3 days
A three-day, hands-on training course in embryo manipulation at Advance, Harwell. Learn microinjection and electroporation techniques for delivering CRISPR-Cas9 reagents, alongside embryo handling and...
1 day
Designed for researchers and students new to genome editing, this course provides a practical foundation in creating and validating genetically altered mouse models. Explore...
1 day
An interactive introduction to genome engineering validation at Advance, Harwell. Learn how long-read sequencing technologies can be used to validate engineered alleles, analyse sequencing...
1 day
Designed for researchers working with conditional mouse models, this course explores the principles behind Cre-Lox, Flp, Dre and Vika systems. Learn how they can...
Find the courses that match your needs, or let us know what you are working toward and we will guide you forward.
Tutors
Specialists in their fields with years of real-world experience.
Senior Pathology technician at the Mary Lyon Centre at MRC Harwell
Adele Austin is a pathology technician based in the Histology lab with over 40 years of experience in...
Clinical Pathology Manager at the Mary Lyon Centre at MRC Harwell
Alex Hardgrave is the Clinical Pathology Manager at the Mary Lyon Centre, MRC Harwell.
Training Lead & Head of Pathology Services at the Mary Lyon Centre at MRC Harwell
Maz is the Training Lead and Head of Pathology Services at the Mary Lyon Centre at MRC Harwell.
Scientific Manager at the Mary Lyon Centre at MRC Harwell
Michelle Stewart is the Scientific Manager at the Mary Lyon Centre at MRC Harwell.
Director of the Mary Lyon Centre at MRC Harwell
Sara Wells is Director of the Mary Lyon Centre at MRC Harwell.